Peer Reviewed
An Unbothersome Rash
Introduction. A 3 year-year-old previously healthy boy presents with a rash that abruptly appeared on his bilateral cheeks, upper arms, buttocks and extending slightly to his lower back and bilateral legs.
History: Although the child is unbothered by the rash, he has had 3 days of cough, rhinorrhea, and sore throat. His father and sister were sick with a viral upper respiratory infection around 1 month ago, the family tested negative for COVID-19, and the patient’s mother denies the patient himself being sick at that time. Physical examination reveals a sick appearing child with unremarkable vital signs. He has bilateral erythematous 3+ tonsils with exudates, bilateral anterior and posterior cervical chain shotty lymphadenopathy, and nasal congestion. The rash is papular, mildly erythematous, and blanching on his bilateral cheeks, posterior upper arms, lower back, buttocks and bilateral legs. It spares the palms and soles. There are no areas of excoriation. (Figures 1-4).

Fig. 1. Posterior right arm
Fig. 2. Posterior left arm
Fig. 3. Anterior trunk and thighs
Fig. 4. Left cheek.Diagnostic Testing: Rapid strep testing in office was negative and a strep culture was sent to the laboratory. Complete blood count with differential, C-reactive protein (CRP), basic metabolic panel, monospot, and Epstein-Barr Virus (EBV) titers were ordered and collected at by an outside laboratory. (Table 1).
Table 1. Laboratory results
Test
Normal Range
Patient Results
White blood cell count
5.0 - 16.0 thousand/uL
12.4
Red blood count
3.90 - 5.50 million/uL
4.19
Hemoglobin
11.5 - 14.0 g/dL
11.5
Hematocrit
34.0 - 42.0 %
35.8
Platelet count
140 - 400 thousand/uL
274
Neutrophils
23 - 45 %
18
Lymphocytes
35 - 65 %
68
Monocyte, absolute
200 - 900 cells/uL
1736/uL
Monocytes
4 - 10 %
14
Neutrophils, absolute
1,500 - 8,500 cells/uL
2,232
Lymphocytes, absolute
2,000 - 8,000 cells/uL
8432/uL
CRP
<8.0 mg/L
1.3
EBV nuclear antigen antibody (IgG)
> 21.99 U/mL
< 18.00
EBV early antigen D antibody
(IgG)
> 10.99 U/mL
>150.00 (H)
EBV capsid antigen (VCA) IgG antibody
> 21.99 U/mL
134.00 (H)
EBV VCA IgM
> 43.99 U/mL
>160.00 (H)
Heterophile, mononucleosis screening (REFL)
Negative
Negative
