ADPKD Leads to Earlier-Onset ESRD in Blacks

While blacks have a lower risk for autosomal dominant polycystic kidney disease (ADPKD), this group progresses to end-stage renal disease (ESRD) quicker than whites with ADPKD, according to results of a study recently presented at the National Kidney Foundation’s 2018 Spring Clinical Meetings.

For their study, the researchers evaluated US Renal Data System data from patients with ESRD secondary to ADPKD for the years 2004 to 2013. Race and age of onset of ESRD were evaluated.

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Participants were grouped by age from 40 years to 75 years, with 10 participants per group.

Results of the researchers’ analysis showed that non-Hispanic blacks were less likely to develop ESRD from ADPKD than non-Hispanic whites. Results were similar after adjusting for US population differences.

However, blacks younger than 40 years had a higher rate of incident ESRD from ADPKD vs whites (9.49% vs 7.68%). In addition, blacks with ADPKD had a younger age of onset of ESRD than whites with ADPKD (54.4 years vs 55.9 years).

“ADPKD incidence in non-Hispanic blacks compared [with] non-Hispanic whites is similar, though slightly lower,” the researchers concluded. “Blacks progress to ESRD at a younger age and thus may be at a higher risk for early progression to ESRD than previously recognized.”

—Amanda Balbi

Reference:

Murphy EL, Dai F, Droher M, et al. ESRD from ADPKD: US incidence is lower but onset is earlier in non-Hispanic blacks compared to non-Hispanic whites. Paper presented at: National Kidney Foundation 2018 Spring Clinical Meetings; April 10-14, 2018; Austin, TX. https://www.nkf2018scm.site/Abstracts/NKFSCM18/Gallery#!/b5d84d0e-6602-4763-8955-acbb1622fc70/abstract/344de7aa-fdf4-4c43-be3c-c8b0b7378a5e/viewer. Accessed April 24, 2018.

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