Understanding Richter Transformation in Chronic Lymphocytic Leukemia

Richter transformation develops in a small subset of patients with chronic lymphocytic leukemia and usually evolves into diffuse large B-cell lymphoma. Conventional approaches such as R-CHOP chemotherapy yield limited benefit, and prognosis remains poor. Newer strategies including chimeric antigen receptor (CAR) T-cell therapy and bispecific antibodies are under investigation. How well do you know the typical survival outcomes with standard therapy?

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