Understanding the Physiologic Basis of Noninvasive Liver Fibrosis Assessment

Chronic liver disease often progresses silently over many years, with fibrosis serving as the key determinant of prognosis and risk for cirrhosis-related complications. Advances in noninvasive testing rely on fundamental changes in liver structure and function that occur as fibrosis evolves. Understanding the underlying pathophysiology of liver fibrosis helps clinicians interpret these tests appropriately and apply them across a range of practice settings.