Identifying Evidence Gaps in the ASH Myelofibrosis Clinical Practice Guidelines

As the ASH Clinical Practice Guidelines on Myelofibrosis move toward publication, the guideline development process itself offers valuable lessons for clinicians who will soon rely on these recommendations. In his interview with Consultant360, Brady L. Stein, MD, MHS, described how the panel’s review of available literature illuminated several limitations inherent to evidence generation in a rare disease. This quiz invites clinicians to explore one of the central observations that emerged from that process and to consider how evidence constraints influence the strength and interpretation of guideline recommendations.

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