Evolving Patterns of Neoadjuvant Systemic Therapy in US Cancer Care

Neoadjuvant systemic therapy (NST) has become an increasingly integral component of multidisciplinary cancer care, with growing evidence supporting earlier systemic treatment in selected solid tumors to downstage disease and improve surgical and oncologic outcomes. A recent analysis using data from the National Cancer Database (NCDB), published in the Journal of the American College of Surgeons, reports substantial increases in the use of NST across multiple cancer types between 2010 and 2022. This quiz series reviews key national patterns in NST adoption, providing insights into how practice is evolving based on comprehensive hospital registry data.

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