Chronic Lymphocytic Leukemia

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FDA Alert
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FDA Alert
FDA Approves Acalabrutinib Plus Venetoclax for First-Line Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
02/20/2026
Ashton L. Stahl
The FDA has approved a chemotherapy-free combination of acalabrutinib and venetoclax for adults with previously untreated CLL or SLL, based on a randomized phase 3 trial demonstrating a progression-free...
02/20/2026
What's Your Diagnosis?
Diffuse pink perifollicular papules on the chest.
What's Your Diagnosis?
Localized Papules in a Man with Weakness and Lightheadedness
01/02/2026
Dayna Gager, BA; Shantelle Griffith, MD; Thomas N. Helm, MD
A 67-year-old man presented after 3 weeks of generalized weakness, lightheadedness, and rash.
01/02/2026
Research Summary
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Research Summary
Bexobrutideg Shows Rapid, Durable Responses in Relapsed/Refractory CLL in Updated Phase 1a Trial Data
12/16/2025
Anthony Calabro, MA
Investigators evaluating the novel Bruton's Tyrosine Kinase degrader bexobrutideg (NX-5948) reported updated Phase 1a results demonstrating rapid and durable clinical responses in heavily pretreated...
12/16/2025

Interactive Features

Pop Quiz
man clutching heart
Pop Quiz
Recognizing Cardiovascular Risks with Ibrutinib
12/09/2025
Anthony Calabro, MA
Ibrutinib, the first-generation Bruton tyrosine kinase inhibitor, has well-documented cardiovascular effects that influence treatment decisions for patients with chronic lymphocytic leukemia. This quiz...
12/09/2025
Pop Quiz
Image of a body with close-up of Chronic Lymphocytic Leukemia cells
Pop Quiz
Evaluating Core Needle Biopsy Sensitivity in Lymphoma Subtypes
11/11/2025
Miranda Manier, BA
Core needle biopsy accuracy varies by lymphoma subtype. Which one yields the highest diagnostic sensitivity? Test your knowledge of hematologic pathology.
11/11/2025
Pop Quiz
Pop Quiz
Pop Quiz
Understanding Richter Transformation in Chronic Lymphocytic Leukemia
10/14/2025
Miranda Manier, BA
Richter transformation of chronic lymphocytic leukemia carries poor outcomes with traditional therapies, but emerging treatments may improve survival. Test your knowledge of prognosis by taking this quick...
10/14/2025
Pop Quiz
docs looking at their charts
Pop Quiz
Chronic Lymphocytic Leukemia Treatment Strategies
09/17/2025
Anthony Calabro, MA
How well do you understand the latest findings on fixed-duration acalabrutinib–venetoclax regimens in untreated chronic lymphocytic leukemia? Take this quiz to find out!
09/17/2025
Pop Quiz
pop quiz
Pop Quiz
A Serious Complication of Chronic Lymphocytic Leukemia
08/13/2025
Anthony Calabro, MA
The survival outcomes for patients diagnosed with this chronic lymphocytic leukemia complication have remained poor for decades. Can you name the complication? Take the quiz to find out!
08/13/2025

Clinical Insights

Expert Q&A
Daniel Lenihan, MD, FACC, FESC, FIC-OS
Expert Q&A
Multidisciplinary Management of Cardiovascular Risk in Patients With CLL on BTK Inhibitors
11/04/2025
Daniel Lenihan, MD, FACC, FESC
Daniel Lenihan, MD, FACC, FESC, FIC-OS, a cardio-oncologist and founder of the International Cardio-Oncology Society, discusses cardiovascular risks associated with Bruton's tyrosine kinase inhibitors in...
11/04/2025