Research Summary
Research Summary
12/16/2025
Anthony Calabro, MA
Investigators evaluating the novel Bruton's Tyrosine Kinase degrader bexobrutideg (NX-5948) reported updated Phase 1a results demonstrating rapid and durable clinical responses in heavily pretreated...
12/16/2025
CONFERENCE COVERAGE
CONFERENCE COVERAGE
12/12/2025
Anthony Calabro, MA
A large, real-world comparative analysis evaluated 1-year clinical and safety outcomes among patients with chronic lymphocytic leukemia receiving venetoclax-based versus Bruton's tyrosine kinase...
12/12/2025
Research summary
Research summary
11/18/2025
Anthony Calabro, MA
A randomized controlled trial evaluated the MyPal eHealth platform’s impact on quality of life among patients with chronic lymphocytic leukemia and myelodysplastic syndromes, revealing significant...
11/18/2025
Research Summary
Research Summary
09/10/2025
Kate Young
Adults 66 years and older with CLL who began treatment with a Bruton’s tyrosine kinase inhibitor were more likely to discontinue early, require subsequent therapy, and experience hospitalization compared...
09/10/2025
Research Summary
Research Summary
07/08/2025
Anthony Calabro, MA
A phase 3 trial confirms that combining ibrutinib with venetoclax yields superior measurable residual disease clearance, progression-free survival, and overall survival in patients with chronic lymphocytic...
07/08/2025
Conference Coverage
Conference Coverage
06/06/2025
Anthony Calabro, MA
Patients with breast cancer and coexisting chronic lymphocytic leukemia (CLL) present with more advanced disease and poorer survival compared with those without CLL, according to the results of a...
06/06/2025
Conference Coverage
Conference Coverage
06/04/2025
Anthony Calabro, MA
Acalabrutinib demonstrated a significantly safer cardiovascular profile and lower mortality risk compared with chemoimmunotherapy in patients with chronic lymphocytic leukemia based on a large retrospective...
06/04/2025
Research Summary
Research Summary
04/08/2025
Miranda Manier, BA
Distinct Bruton tyrosine kinase mutation patterns emerged in chronic lymphocytic leukemia progression on acalabrutinib vs ibrutinib, highlighting resistance differences.
04/08/2025
Research Summary
Research Summary
03/10/2025
Anthony Calabro, MA
In their phase 3, open-label trial, Brown and colleagues set out to address the need for more effective first-line treatment strategies for fit patients with untreated CLL.
03/10/2025
Research Summary
Research Summary
01/14/2025
Miranda Manier, BA
A recent phase 3 study found that venetoclax-obinutuzumab improves progression-free survival and quality of life compared with chlorambucil-obinutuzumab in patients with untreated chronic lymphocytic...
01/14/2025