HIV Prevention

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Research Summaries

CROI 2025 Conference Coverage

CROI 2025 Conference Coverage

Low Uptake of HIV PrEP Among At-Risk US Adolescents, Young Adults

12/08/2015

Anthony Calabro, MA

A new analysis of US claims data examined preexposure prophylaxis prescribing patterns among commercially insured adolescents and young adults at increased risk for HIV, offering clinicians insights into...

12/08/2015

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Pre-exposure prophylaxis (PrEP) is a preventive medication administered intravenously or orally to reduce the risk of human immunodeficiency virus (HIV) infection that may occur following sex or injection drug use.

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Any licensed health care provider can prescribe PrEP. Among clinicians who are most likely to prescribe PrEP are:

primary care providers; internal medicine specialists; infectious disease specialists

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Individuals at risk of HIV transmission include:

People who have had anal or vaginal sex in the past 6 months and:
- had a partner with HIV

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Individuals at risk of HIV transmission include:

People who have had anal or vaginal sex in the past 6 months and:
- had sex without consistently using a condom

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Individuals at risk of HIV transmission include:

People who have had anal or vaginal sex in the past 6 months and:
- have been diagnosed with a sexually transmitted disease in the past 6 months

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Individuals who are at risk of HIV transmission include:

Individuals who inject drugs, have an injection partner with HIV, or share needles, syringes, or other drug injection equipment

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Individuals who are at risk of HIV transmission include:

Individuals who have previously been prescribed PrEP, have reported continued risky behavior, or previously used multiple courses of PrEP

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The HIV Risk Incidence Index for Men Who Have Sex With Men (HIRI-MSM) and Injection Drug Users Risk Index (IDU) are often used to stratify risk in patients.

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PrEP may reduce HIV transmission from sex by 99% when taken as prescribed.

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The use of PrEP among recommended users increased from 3% in 2015 to 25% in 2020.

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Sources:

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HIV Prevention Snapshot

Reviewed by Daniel Erias, MD and Jeffrey Kwong, DNP, MPH, AGPCNP-BC

Research Summaries

Research Summary

Research Summary

Randomized Trial Finds 4CMenB Does Not Reduce Gonorrhea in MSM With Recent STIs

08/13/2026

Ashton L. Stahl

A randomized trial evaluated whether the 4CMenB vaccine prevents gonorrhea among adults at high risk for infection.

08/13/2026

Research Summary

Research Summary

US Claims Study Finds Modest Uptake of Injectable Cabotegravir PrEP

08/06/2026

Ashton L. Stahl

A US prescription claims study evaluated uptake and 2-year persistence among users of long-acting injectable cabotegravir for HIV PrEP.

08/06/2026

Research Summary

Research Summary

Value Analysis: Improving TDF-FTC PrEP Uptake Could Yield Billions in Health System Value for YMSM

07/08/2026

Anthony Calabro, MA

Improving TDF-FTC uptake among US young men who have sex with men on HIV PrEP could yield substantial 10-year value, while a hypothetical study eliminating adverse event uncertainty would not change the...

07/08/2026

Research Summary

Research Summary

Dapivirine Ring, Oral PrEP Show Safety in Second-Trimester Pregnancy

04/06/2026

Kate Young

In a phase 3b trial, monthly dapivirine ring and daily oral PrEP were assessed for safety, adherence, and acceptability in pregnancy.

04/06/2026

Research Summary

Research Summary

Comparing CBO, DTC Delivery of the Keep It Up! Digital HIV Prevention Program

02/09/2026

Anthony Calabro, MA

A type III hybrid effectiveness–implementation trial compared community-based organization versus direct-to-consumer delivery of the Keep It Up! digital HIV prevention intervention for young men who have...

02/09/2026

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