The FDA approved tebipenem pivoxil (Utebzi) for adults with complicated urinary tract infections, including pyelonephritis, who have limited or no alternative oral treatment options.
In an international Bayesian adaptive RCT of adults with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin for 90-day all-cause mortality and was associated with less acute kidney...
The FDA approved cefepime and zidebactam (Zaynich, Wockhardt), a novel intravenous antibiotic, for adults with complicated urinary tract infections, including pyelonephritis, caused by susceptible...
A large cohort study from a quaternary health center found that using β-lactam antibiotics for surgical prophylaxis significantly lowered the risk of surgical site infections compared with non–β-lactam...
Large-scale evidence shows perioperative dexamethasone reduces infection risk and shortens hospital stay in patients with diabetes undergoing joint arthroplasty, though hyperglycemia remains a concern.
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Debridement, Antibiotics, and Implant Retention (DAIR) achieved comparable long-term outcomes whether performed within 4 weeks or between 5 and 12 weeks after arthroplasty for acute prosthetic joint...
A retrospective study finds that early surgical debridement in diabetic foot ulcers complicated by osteomyelitis significantly improves healing time, infection control, and amputation rates compared with...
A large database study reveals a dose-dependent association between opioid use and risk of surgical and medical complications following primary shoulder arthroplasty.
A retrospective analysis of more than 38,000 patients found that outpatient revision total knee arthroplasty is not associated with higher rates of perioperative complications or repeat revisions compared...
An 8-year study reveals high rates of ipsilateral fractures and Charcot neuroarthropathy after pedal-level amputations in patients with diabetes, especially following great toe amputation.
