In a phase 3 BWEL substudy, a lifestyle-based weight loss intervention improved patient-reported physical function, global health, social roles and activities, and fatigue in women with stage II-III breast...
The FDA approved Enhertu for neoadjuvant treatment of adults with HER2-positive stage II or III breast cancer and adjuvant treatment of patients with residual invasive disease after neoadjuvant therapy.
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On May 1, the FDA approved vepdegestrant (Veppanu), a heterobifunctional protein degrader, for adults with estrogen receptor–positive, human epidermal growth factor receptor 2–negative, ESR1-mutated...
A large multinational cohort study evaluated whether COVID-19 vaccination during pregnancy reduces the risk of preeclampsia, a major hypertensive complication associated with SARS-CoV-2 infection.
Maternal COVID-19 vaccination was linked with fewer severe maternal outcomes; early mRNA vaccination showed no rise in malformations; in utero infection was tied to higher neurodevelopmental diagnoses.
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A longitudinal analysis from the Western Australian Raine Study evaluated whether polycystic ovary syndrome coexisting with metabolic dysfunction–associated steatotic liver disease during adolescence is...
Elevated maternal blood pressure during pregnancy has long been associated with adverse pregnancy outcomes, but causal inference has remained challenging. A large Mendelian randomization study now clarifies...
