Initiation of urate-lowering therapy (ULT) is frequently complicated by acute gout flares, and the need for safe and effective prophylaxis remains a challenge in clinical practice. A new phase 2 trial from...
In a 12-week, multicenter, randomized, double-blind, placebo-controlled phase 2b trial, the selective hURAT1 inhibitor epaminurad produced rapid, dose-dependent reductions in serum urate in adults with...
In a qualitative study of physicians managing patients with primary hyperoxaluria type 1 (PH1), presented at Kidney Week 2025, clinicians emphasized simplicity, patient convenience, and ease of...
In a phase 4 trial, 60-minute pegloticase infusions co-administered with methotrexate demonstrated safety, tolerability, and efficacy comparable to the standard 120-minute duration, with a 67% treatment...
A recent study examining gout and chronic kidney disease found that achieving a serum urate level below 6 mg/dL with urate-lowering therapy does not increase the risk of severe or end-stage kidney disease...
In the PROTECT trial, 89% of kidney transplant recipients with uncontrolled gout achieved sustained urate lowering with pegloticase, alongside meaningful improvements in quality of life, blood pressure, and...
A multi-center study finds kidney transplantation from HIV-positive donors to HIV-positive recipients is as safe and effective as using kidneys from HIV-negative donors, offering new insights into expanding...
A phase 3 trial shows that adding voclosporin to mycophenolate mofetil and low-dose glucocorticoids leads to higher rates of complete renal response and faster reduction in proteinuria for patients with...
Researchers developed a cohort study of more than 14,000 participants to determine whether there is an association between statin initiation and a reduced risk of mortality and major adverse cardiovascular...
The development of new treatment options for nephropathic cystinosis has resulted in a higher likelihood of survival to adulthood for these patients but has also introduced new challenges in management....
