On May 1, the FDA approved vepdegestrant (Veppanu), a heterobifunctional protein degrader, for adults with estrogen receptor–positive, human epidermal growth factor receptor 2–negative, ESR1-mutated...
A large multinational cohort study evaluated whether COVID-19 vaccination during pregnancy reduces the risk of preeclampsia, a major hypertensive complication associated with SARS-CoV-2 infection.
Maternal COVID-19 vaccination was linked with fewer severe maternal outcomes; early mRNA vaccination showed no rise in malformations; in utero infection was tied to higher neurodevelopmental diagnoses.
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A longitudinal analysis from the Western Australian Raine Study evaluated whether polycystic ovary syndrome coexisting with metabolic dysfunction–associated steatotic liver disease during adolescence is...
Elevated maternal blood pressure during pregnancy has long been associated with adverse pregnancy outcomes, but causal inference has remained challenging. A large Mendelian randomization study now clarifies...
A large contemporary U.S. electronic health record analysis highlights elevated risks of severe maternal morbidity and preterm birth among pregnant individuals with sickle cell disease, offering updated...
On November 10, the U.S. Department of Health and Human Services announced that the FDA is initiating the removal of certain black box warnings from hormone replacement therapy products for menopause,...
A phase 2 nonrandomized clinical trial explored whether breast surgery could be safely eliminated for women with ERBB2-positive or triple-negative invasive breast cancer who achieved a pathologic complete...
