Peer Reviewed

Parkinson Disease

Osteoarthritis Is Linked to Increased Parkinson Disease Risk

Osteoarthritis (OA) is associated with an increased risk of developing Parkinson disease (PD), according to the results of a recent study.1

The researchers conducted a retrospective cohort study using data from Taiwan’s Longitudinal Health Insurance Database 2005, including 33,360 patients aged 50 to 64 years with OA and 33,360 age- and sex-matched individuals without OA.

Overall, the researchers observed a significantly higher risk of developing PD (adjusted hazard ratio [aHR] 1.41, 95% CI 1.16-1.70) among the patients with OA compared with the patients.

A subgroup analysis found that patients with knee or hip OA seemed to have a higher risk of P (aHR 1.55, 95% CI 1.14–2.11) than did patients with other forms of OA (aHR 1.42, 95% CI 1.06–1.89) or uncategorized OA (aHR 1.32, 95% CI 1.05–1.64).

"Coexisting osteoarthritis and Parkinson's disease can additively increase the risk of falling. Moreover, osteoarthritis-related mobility impairments may mask early motor symptoms of Parkinson's disease," the authors said in a press release. "Health professionals need to be alert to the potential link between these two diseases."2

—Michael Potts


  1. Feng S, Chuang H, Yeh K, Pan S. Osteoarthritis is associated with an increased risk of Parkinson’s disease: A population-based, longitudinal follow-up study. Published online June 8, 2021. Arthritis Care Res.
  2. Osteoarthritis linked to higher Parkinson's disease risk. News release. Wiley; June 9, 2021. Accessed June 9, 2021.