Protein Pacing Diet Reduces Weight and Oxidative Stress

A balanced, protein-pacing, low-calorie diet that incluedes intermittent fasting helps individuals to achieve long-term weight loss, improves heart health, and reduces oxidative stress, according to a recent study.

The study sought to determine the best methods of weight loss for obese men and women that reduces the amount of polychlorinated biphenyls (PCBs) toxins stored in adipose tissues, and to reduce the adverse effects of PCBs.
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The study included 21 obese men and 19 obese women who completed a 12-week protein-pacing caloric restriction weight loss intervention, and either completed a 52-week modified protein-pacing caloric restriction weight loss intervention or a heart healthy diet. Serum PCBs and oxidative stress biomarkers, thiobarbituric acid reactive substances and total antioxidant capacity were assessed at weeks -1, 12, and 64.

At week 12, researchers noted reductions in thiobarbituric acid reactive substances, PCB serum, and increased levels of total antioxidant capacity in both men and women. At 64 weeks, participants on the modified protein-pacing weight loss intervention had higher values of PCB serum than the heart healthy diet participants, which demonstrated a correlation between high PCB circulation with lower weight in obese participants. According to the researchers, the PCB changes were positively correlated with thiobarbituric acid reactive substance levels, and negatively correlated with body weight, fat mass, and abdominal fat.

"Our results support mobilization of stored PCBs as well as enhanced redox status following a 12-week [protein-pacing calorie restriction] diet. Additionally, a 52-week [protein-pacing calorie restriction] diet demonstrated an advantage in preventing weight gain relapse accompanied by an increase in circulating PCBs compared to a traditional [heart healthy] diet."

—Melissa Weiss


He F, Zuo L, Ward E. and Arciero PJ. Serum polychlorinated biphenyls increase and oxidative stress decreases with a protein-pacing caloric restriction diet in obese men and women [published online January 10, 2017]. International Journal of Environmental Research and Public Health. doi: 10.3390/ijerph14010059.