Quality of Sleep Could Significantly Increase Risk of End Stage Renal Disease

Short-term and poor quality sleep are underappreciated risk factors for chronic kidney disease (CKD), according to recent research.

Specifically, each additional hour of sleep among study participants was linked to a 19% decreased risk of developing CKD.
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While previous research has suggested an increased likelihood of sleep disorders among patients with CKD, the effects of these disorders on CKD are not well understood.

For their study, researchers examined data from 432 adults who wore wrist actigraph for 5-7 days to measure sleep duration and quality. Daytime sleepiness, apnea risk, and subjective sleep quality were self-reported. Cox proportional hazard models were used to evaluate risk of end stage renal disease (ESRD) and all-cause death.

Overall, participants slept an average of 7.4 hours per night, with mean sleep fragmentation of 21%. Over a median follow-up of 5 years, 70 ESRD events and 48 deaths were observed. After adjusting for factors including body mass index, blood pressure, diabetes, cardiovascular disease, and kidney function, longer sleep was associated with 19% lower risk of ESRD per hour increase in duration, and higher sleep fragmentation was associated with 4% increased ESRD risk per 1% increase in fragmentation.

Daytime sleepiness was associated with 10% increased risk for all-cause mortality, and no significant association between sleep start time, self-reported sleep quality or apnea risk was observed.

The findings were reported at the American Society of Nephrology Kidney Week 2016 at McCormick Place in Chicago, IL.

“These findings suggest that short and poor quality sleep are unappreciated risk factors for CKD progression.”

—Michael Potts

Reference:

Ricardo AC, Knutson K, Chen J, et al. The association of sleep duration and quality with chronic kidney disease progression [paper presented at American Society of Nephrology Kidney Week 2016]. November 19, 2016. Chicago, Illinois.