Certain NSAIDs May Increase Risk of Heart Attack, Stroke in Women
Researchers from the University of Florida suggest that consistent use of the NSAID naproxen—the active ingredient in Aleve—is correlated with a 10% increased risk of adverse cardiovascular events in postmenopausal women.
Cox-2 Users at Risk When Not Taking GI Agents
Protecting Hearts and Heads in the NSAID Era
The study included data from 160,000 postmenopausal women who were surveyed through the Women’s Health Initiative (a 15-year study), and showed that 53,142 women regularly used NSAIDs.
Even after adjusting for obesity, hypertension, diabetes, and aspirin use, the use of NSAIDs, especially Cox-2 inhibitors and nonselective agents with Cox-2>Cox-1 inhibition, was still associated with heightened risk of heart attack, stroke, and death.
NSAIDs with Cox-1>Cox-2 inhibition (ibuprofen) were not associated with elevated risk of heart attack or stroke, leading researchers to believe that Cox-2 inhibition plays an important role in the risk of adverse cardiovascular events.
Researchers encouraged patients to use NSAID’s only in the short-term and to further consult with their doctors to monitor for any risk of heart disease.
The complete study is published in the July issue of Circulation: Cardiovascular Quality and Outcomes.
Bavry AA, Fridtjof T, Allison M, et al. Nonsteroidal anti-inflammatory drugs and cardiovascular outcomes in women. Circ Cardiovasc Qual Outcomes. 2014 July [epub ahead of print] doi: 10.1161/ CIRCOUTCOMES.113.000800.
University of Florida. UF research finds association between certain pain relievers and heart attack [press release]. July 9, 2014. http://news.ufl.edu/2014/07/09/nsaid-risks-for-women/.Accessed July14, 2014.