An Atlas of Lumps and Bumps: Part 17
1Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada
2Alberta Children’s Hospital, Calgary, Alberta, Canada
3Toronto Dermatology Centre, Toronto, Ontario, Canada
4Department of Pediatrics and Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
5Medical staff, Asian Medical Clinic, an affiliate with the University of Calgary Medical Clinic, Calgary, Alberta, Canada
6Pediatric Institute, Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia
Leung AKC, Barankin B, Lam JM, Leung AAM, Leong KF. An atlas of lumps and bumps, part 17. Consultant. 2022;62(6):e36-e38. doi:10.25270/con.2022.06.00012
Dr Leung is the series editor. He was not involved with the handling of this paper, which was sent out for independent external peer review.
Alexander K. C. Leung, MD, #200, 233 16th Ave NW, Calgary, AB T2M 0H5, Canada (email@example.com)
This article is part of a series describing and differentiating dermatologic lumps and bumps. To access previously published articles in the series, visit https://www.consultant360.com/resource-center/atlas-lumps-and-bumps.
Thyroglossal Duct Cyst
Embryologically, the thyroid anlage arises from the primitive pharynx at the site of the future foramen cecum (at the junction of the anterior two-thirds and posterior one-third of the tongue) at around the third week of gestation.1,2 As the neck develops, the thyroid gland descends along the midline of the neck, between the first and second branchial arteries, and ventral to the hyoid bone and the developing laryngeal cartilage by the seventh week of gestation.1-3 The thyroid gland remains connected to the foramen cecum by the thyroglossal duct during the descent. The thyroglossal duct usually involutes by the tenth week of gestation.1 Failure of involution of any portion of the thyroglossal duct and secretion from the epithelial lining of the duct results in the formation of a thyroglossal duct cyst.1
Thyroglossal duct cysts occur in approximately 7% of the general population.1,4 The sex ratio is approximately equal.5,6Most cases are sporadic.2,7 Familial occurrence is unusual.2Thyroglossal duct cysts are occasionally inherited as an autosomal dominant disorder or, rarely, as an autosomal recessive disorder.2
Typically, a thyroglossal duct cyst presents as a painless midline neck cystic mass (Figures 1 and 2) at any site along the normal pathway of descent from the foramen cecum to the inferior neck.2,4 In the pediatric age group, most thyroglossal duct cysts are 2 cm to 4 cm in diameter.3 Larger thyroglossal duct cysts are seen mainly in adults.3 The most common site of a thyroglossal duct cyst (61% of cases) is between the thyroid gland and the hyoid bone.8 Other potential sites include the suprahyoidal (24%), suprasternal (13%), or intralingual (2%) locations.8-10 A thyroglossal duct cyst may move upward with deglutition and with protrusion of the tongue.2,4,11 Typically, the cyst is mobile from side to side, but the movement may be limited with protrusion of the tongue because of its persistent attachment to the foramen cecum.2 Approximately 1% of the cysts are located laterally, often on the left side.8 Although thyroglossal duct cysts are congenital, these lesions rarely present in the neonatal period.2 More commonly, the cysts are noted in preschool children, sometimes after an upper respiratory tract infection with rapid enlargement of the cysts.2,3 Otherwise, most thyroglossal duct cysts tend to grow slowly over time.6 Up to 50% of the lesions are not diagnosed until the second decade of life.12 Some thyroglossal duct cysts do not present until adulthood.3
Figure 1. Thyroglossal duct cyst presenting as cystic mass at midline neck.
Figure 2. Thyroglossal duct cyst presenting as cystic mass at midline neck.
Infection is the most common complication and is seen in approximately 10% of affected patients.5,11Hemorrhage into the cyst may also occur.6 A lingual thyroglossal duct cyst may result in dysphagia, speech impairment, and ball-valve obstruction of the larynx.8,13 Extrinsic airway compression or intralaryngeal extension may result in hoarseness, obstructive sleep apnea, and dyspnea.8,14,15 A thyroglossal duct cyst has the potential for malignant transformation during childhood, but this is uncommon.2 Approximately 99% of thyroglossal duct malignancies are papillary adenocarcinomas.11,16,17 Squamous cell carcinoma in a thyroid duct cyst is rare but has been reported.18
External Angular Dermoid
An external angular dermoid is a dermoid cyst located at the lateral eyebrow or the orbital rim adjacent to the frontozygomatic suture. The cyst arises along bony sutures as a result of abnormal ectodermal sequestration during embryonic development.19,20 The cyst lining consists of keratinized stratified squamous epithelium.19 The cavity is filled with mature dermal derivatives such as hair follicles, sweat and sebaceous glands, and fibroadipose tissue, with varying amounts of keratinous material.19 Dermoid cysts in children are commonly found in the head and neck regions, accounting for up to 84% of total body dermoid cysts.21 Dermoid cysts that involve the lateral eyebrows or eyelid account for more than 50% of dermoid cysts in the head and neck regions.19,22Most cases are sporadic, and familial occurrence has rarely been reported.20
Clinically, an external, angular dermoid presents as an asymptomatic, soft to firm, poorly mobile, solitary mass above the lateral eyebrow (Figures 3 and 4).19-22 The mass is subcutaneous, and the overlying skin is normal.23 The mass is usually noticed at birth or in the first year of life.19 An external angular dermoid is generally benign and slow-growing.19,21 However, an external angular dermoid may cause a bony depression from pressure or may have a dumb-bell extension into the orbit. Rupture of the dermoid cyst into the subcutaneous tissue can result in a severe granulomatous inflammation.
Figure 3. Angular dermoid presenting as an asymptomatic, solitary mass above the lateral eyebrow.
Figure 4. Angular dermoid presenting as an asymptomatic, solitary mass above the lateral eyebrow.
1. Amos J, Shermetaro C. Thyroglossal duct cyst. In: StatPearls [internet]. StatPearls Publishing; 2020.
2. Leung AKC. Thyroglossal duct cyst. In: Lang F, ed. The Encyclopedia of Molecular Mechanisms of Disease. Berlin: Springer-Verlag: 2009;2069-2070.
3. Mortaja S, Sebeih H, Alobida NW, Al-Qahtani K. Large thyroglossal duct cyst: A case report. Am J Case Rep. 2020;21:e919745. doi:10.12659/AJCR.919745
4. Rawl JW, Rossi NA, Yantis MG, Szeremeta W. Thyroglossal duct cyst anterior to the sternum: a novel presentation of a common lesion. BMJ Case Rep. 2020;13(11):e236515. doi:10.1136/bcr-2020-236515
5. Foti J, Grimaldo F. Infected recurrent thyroglossal duct cyst: A case report. Clin Pract Cases Emerg Med. 2020;4(3):411-413. doi:10.5811/cpcem.2020.4.46863
6. Valentino M, Quiligotti C, Villa A, Dellafiore C. Thyroglossal duct cysts: Two cases. J Ultrasound. 2012;15(3):183-185. doi:10.1016/j.jus.2012.04.003
7. Atmaca S, Çeçen A, Kavaz E. Thyroglossal duct cyst in a 3-month-old infant: A rare case.Turk Arch Otorhinolaryngol. 2016;54(3):138-140. doi:10.5152/tao.2016.1636
8. Soliman AM, Lee JM. Imaging case study of the month. Thyroglossal duct cyst with intralaryngeal extension. Ann Otol Rhinol Laryngol. 2006;115(7):559-562. doi:10.1177/000348940611500711
9. Park MJ, Shin HS, Choi DS, et al. A rare case of thyroglossal duct cyst extending to the sublingual space: A case report. Medicine (Baltimore). 2020;99(17):e19389. doi:10.1097/MD.0000000000019389
10. Turri-Zanoni M, Battaglia P, Castelnuovo P. Thyroglossal duct cyst at the base of tongue: The emerging role of transoral endoscopic-assisted surgery. J Craniofac Surg. 2018;29(2):46