Is Systemic Lupus Erythematosus Linked to Malignant Melanoma?
Being diagnosed with systemic lupus erythematosus (SLE) is associated with a significant increase in the risk of developing malignant melanoma, according to the results of a recent study.
SLE has previously been linked to other cancers, including non-Hodgkin and Hodgkin lymphomas, and lung, larynx, liver, vulva, vagina, and thyroid gland cancer.
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For their study, researchers analyzed medical records from 2351 patients with SLE diagnosed between 2000 and 2016, and a comparison group of 1676 patients with systemic sclerosis.
Overall, 10 participants (0.4%) with SLE were later diagnosed with malignant melanoma, compared with just 1 participants with sclerosis (0.06%).
Study limitations included a lack of information on the time between SLE diagnosis and diagnosis of melanoma, and the rates or cumulative exposure to checkpoint inhibitors.
SLE linked to subsequent risk of malignant melanoma. Rheumatology News. May 11, 2017. http://www.mdedge.com/rheumatologynews/article/138039/lupus-connective-tissue-diseases/sle-linked-subsequent-risk.