Heart attack

Study: Common Antacid Could Raise Heart Attack Risk By 21%

Adults who use proton pump inhibitors (PPIs) have a 16% to 21% increased chance of having a heart attack compared to those not using that form of antacid, according to a recent study.

“Proton pump inhibitors (PPIs) have been associated with adverse clinical outcomes amongst clopidogrel users after acute coronary syndrome. Recent pre-clinical results suggest that this risk might extend to subjects without any prior history of cardiovascular disease,” explained the study’s authors.
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To examine whether PPI use was linked to cardiovascular risk in the general population, researchers collected clinical data from 2.9 million participants and compared heart attack risk in individuals using PPIs against risk in those using other similar drugs, such as H2 blockers.

The study showed that gastroesophageeal reflux disease (GERD) patients who used PPIs had a 1.16-1.21 fold heightened risk of heart attack, while H2 blockers showed no association to heightened cardiovascular risk.

Researchers noted that, due to uncertainties in the estimation process, the estimated increased risk of heart attack ranges from 16% to 21%.

“Our results demonstrate that PPIs appear to be associated with elevated risk of MI in the general population; and H2 blockers show no such association,” they concluded.

“The associations are independent of clopidogrel use or age-related risks and are seen in two large independent datasets and a prospective cohort. In particular, the association is seen outside of the high-risk populations previously examined, such as the elderly or patients with acute coronary syndrome.”

The complete study is published in the June issue of PLOS one.

-Michelle Canales Butcher

Reference:
Shah NH, LePendu P, Bauer-Mehren A, et al. Proton pump inhibitor usage and the risk of myocardial infarction in the general population. PLOS one. 2015 June [epub ahead of print] doi: 10.1371/journal.pone.0124653.