Sleep Apnea

OSA, Insomnia Highly Prevalent in Neurological Patients

High-risk obstructive sleep apnea (OSA) and insomnia are highly prevalent in neurological patients and can be associated with worse disease-specific outcomes, according to new research.

With these findings in mind, the authors of the study recommend “routine screening of common, treatable sleep disorders in neurological populations.”

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Their findings emerged from a study of 9159 patients in the Adult Psychiatry (AP), Movement Disorders (MD), Cerebrovascular (CV), Brain Tumor (BT), and Epilepsy (EP) Centers at the Cleveland Clinic Neurological Institute in Ohio.

Loud Snoring, Tiredness, Observed apnea, high blood Pressure (STOP) and Insomnia Severity Index (ISI) scores were recorded at each patient’s first outpatient visit between March 2015 and October 2016.

Multivariate logistic regression models were used to assess the association of high-risk OSA and significant insomnia with disease-specific outcomes based on various tests—such as the Patient Health Questionnaire-9 (PHQ-9) and the Unified Parkinson Disease Rating scale (UPDRS-II).

A total of 7979 patients completed STOP, and 8799 completed ISI. Findings from the study revealed that the crude prevalence of high-risk OSA and significant insomnia were higher in CV (47.89) and AP populations (33.64)

In multivariate logistic regression, the researchers observed a higher likelihood of insomnia (odds ratio [OR] 1.584) in the BT population based on difference in ISI score. Furthermore, based on difference in STOP scores, a higher likelihood of high-risk OSA was observed in BT (OR 1.427), CV (OR 1.912), and EP populations (OR 1.48).

In particular, a significant association of PHQ-9 scores with high-risk OSA and insomnia and of UPDRS-II with insomnia were observed in individual models.

These findings were presented on April 22 at the 2018 American Academy of Neurology Annual Meeting in Los Angeles, California.

—Christina Vogt


Somboon T, Walia H, Kinzy TG, Katzan I, Foldvary-Schaefer N. Prevalence of high risk obstructive sleep apnea and insomnia ascertained by STOP and insomnia severity index in neurological populations. Paper presented at: 2018 American Academy of Neurology Annual Meeting; April 21-27, 2018; Los Angeles, CA.