Hepatitis C

Can switching statins impact hepatitis c treatment?

Switching statins, compared with maintained or interrupted use, did not impact total cholesterol or the rates of adverse events in patients with hepatitis C taking glecaprevir/pibrentasvir (G/P), according to a recent study.

Currently, certain statins are not recommended for concomitant use with G/P in patients with chronic hepatitis C virus infection.
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In order to examine the impact of switching to rosuvastatin or pravastatin compared with maintaining or interrupting current statin use, researchers collected the safety and efficacy data of 2369 HCV-infected GT 1-6 patients treated with G/P. The patients were grouped by those who switched from a non-recommended to recommended statin, maintained the same statin, or interrupted statin use prior to G/P treatment.

Overall, 135 of the 2369 patients received statins prior to G/P therapy, with 35 switching to a recommended statin, 43 maintaining the same statin, and 57 interrupting statin use. Mean total cholesterol increased by 6.1 mg/dL and 8.6 mg/dL in patients who switched or maintained statins, respectively, and increased by 18 mg/dL in those who interrupted statin use. Rates of adverse events were similar across the 3 groups, and sustained virologic response at 12 weeks was 98% or higher in all subgroups managing statins.

“Switching statins did not impact total cholesterol or the types and rates of reported AEs in patients receiving G/P. High SVR12 rates were observed in all groups.”

—Michael Potts

Reference:

Kwo P, Jones P, Barcomb L, et al. 1129-411 / 411 - Safety and efficacy of statin management during glecaprevir/pibrentasvir treatment for chronic hepatitis C [presented at the ACC’s 67th Annual Scientific Session and Expo]. March 10, 2018. http://www.abstractsonline.com/pp8/#!/4496/presentation/39488.