Could Cinnamon Prevent Diabetes Progression?
Cinnamon supplementation could help to prevent patients with prediabetes from progressing to type 2 diabetes (T2D), according to the results of a recent study.
While cinnamon has been shown to have glucose-lowering properties, whether these could be employed in patients with prediabetes to prevent disease progression is unknown.
To examine this possibility, the researchers conducted a double-blind, randomized, controlled trial involving 54 adults with prediabetes. The participants were randomly assigned to receive either 500 mg of cinnamon supplementation (n=27) or placebo (n=27) 3 times a day for 12 weeks.
Overall, increases in fasting plasma glucose (FPG) were observed in participants from the placebo group, but not in those from the cinnamon group. The mean between-group difference in FPG was 5 mg/dL (P<0.05). Compared with the collective baseline of all participants, cinnamon was associated with a significant decrease in the area under the curve plasma glucose (P<0.001) and of the 2-hr plasma glucose of the oral glucose tolerance test (P<0.05).
“In individuals with prediabetes, 12 weeks of cinnamon supplementation improved FPG and glucose tolerance, with a favorable safety profile. Longer and larger studies should address cinnamon’s effects on the rate of progression from prediabetes to T2D,” the researchers concluded.
Romeo GR, Lee J, Mulla CM, et al. Influence of cinnamon on glycemic control in subjects with prediabetes: a randomized controlled trial. Published online July 21, 2020. JES. doi:10.1210/jendso/bvaa094