Peer Reviewed


Rumination Syndrome and Functional Dyspepsia: Do They Overlap?

Rumination syndrome (RS) is more common than expected in patients with functional dyspepsia (FD), suggesting that the two could share a pathophysiology, according to the results of a recent study.

“A significant proportion of patients with RS are reported to have FD symptoms, however, the associations of RS have not been reported at a population level,” the researchers wrote.

In order to investigate the potential overlap between the two conditions, the researchers surveyed 2901 individuals on gastrointestinal symptoms, diet, anxiety and depression, and somatic symptoms.

Overall, 4% and 6.9% of participants had RS and FD, respectively. In patients with FD, the prevalence of RS was 10.3%. A significant overlap in psychiatric risk factors and lesser overlaps in allergic and immune mediated disorders were observed between the two conditions.

“RS is found more frequently in patients with FD than expected by chance, suggesting an overlapping pathophysiology. RS is found in association with disorders characterized by immune activation. The different risk factor profile of the two disorders found in this community sample, however, suggests separate disease processes,” they concluded.

—Michael Potts


Irani MZ, Jones MP, Herrick LM, et al. Rumination syndrome and functional dyspepsia overlap more than expected by chance in a population-based study but have different risk factors. Presented at Digestive Disease Week 2021. May 21, 2021.