disease development

Certain Characteristics Correlated With Late-onset Psoriatic Arthritis

The incidence of late-onset psoriatic arthritis (PsA) occurred more frequently in men and was associated with worse functionality and more structural damage than individuals with early-onset PsA, according to a study recently presented at the American College of Rheumatology Convergence 2022.

Researchers sought to find clinically relevant variances to predict the development and prognosis of the disease depending on the age of onset of the symptoms to execute a more comprehensive follow-up.

Included in this observational study were a subgroup of 231 patients with PsA from the REGISPONSER and RESPONDIA studies. Patients were divided into two groups according to the age of PsA onset (early-onset: ≤ 40 years old and late-onset: ≥ 60 years old). Binary logistic regression was conducted to ascertain factors linked with late-onset PsA.

Of the 231 patients, 77.5% (n = 179) were classified as early-onset and 22.5% (n = 52) as late-onset. In the late-onset group there was a higher percentage of men than women, 62.3% (n = 94) vs 86.4% (n = 38). A lower incidence of sacroiliitis was discovered in patients with late-onset PsA, 12.2% (n = 6) vs 32.6% (n = 58), as well as enthesitis, 9.8% (n = 5) vs 24.6% (n = 44).

Those with late-onset PsA had a greater incidence of cardiovascular disease, higher scores in the Bath Ankylosing Spondylitis Functional Index (BASFI), and lower scores in FSF12 component. The radiographic indices measured by the Bath Ankylosing Spondylitis Radiology Index (BASRI) revealed worse results in those patients with late-onset disease both in the spine and in the total BASRI.

The authors indicated that their findings suggests that the age of onset of PsA was correlated with different characteristics of the disease.  

“Quality of life, disease activity, and treatments taken were not associated significantly with age of onset. Late-onset PsA is associated with [men], greater structural damage, higher frequency of arthritis (upper limbs), and greater loss of functionality (BASFI),” researchers concluded. “Finally, it is associated with a shorter diagnostic delay, lower frequency of enthesitis and sacroiliitis.”


—Yvette C Terrie, BS. Pharm, R.Ph.



Puche Larrubia M, Ladehesa-Pineda l, López Montilla M, Granados R, Collantes E, Lopez-Medina C. Differences in Early-onset vs. Late-onset Psoriatic Arthritis: Data from the RESPONDIA and REGISPONSER Studies [abstract]. Paper presented at: American College of Rheumatology Convergence 2022; November 10-14, 2022; Philadelphia, PA. Accessed November 10, 2022.